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Umbilical cord-derived mesenchymal stem cells: strategies, challenges, and potential for cutaneous regeneration

Siming Yang, Sha Huang, Changjiang Feng, Xiaobing Fu

Frontiers of Medicine 2012, Volume 6, Issue 1,   Pages 41-47 doi: 10.1007/s11684-012-0175-9

Abstract:

Umbilical cord mesenchymal stem cells (MSCs) are a unique, accessible, and non-controversial sourceof early stem cells that can be readily manipulated.the most common pluripotent cell, bone marrow-derived MSCs display limitations with the progress of stemBy contrast, umbilical cord-derived cells, which have plentiful resources, are more accessible.

Keywords： umbilical cord     mesenchymal stem cells     cutaneous regeneration    

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Mesenchymal stem cells hold promise for regenerative medicine

Shihua Wang, Xuebin Qu, Robert Chunhua Zhao

Frontiers of Medicine 2011, Volume 5, Issue 4,   Pages 372-378 doi: 10.1007/s11684-011-0164-4

Abstract: an emerging interdisciplinary field of research that uses several technological approaches including stemcells to repair tissues.Mesenchymal stem cells (MSCs), a type of adult stem cell, have generated a great amount of interest overmechanisms through which MSCs exert their therapeutic potential rely on some key properties of the cellsinto osteoblasts, chondrocytes, adipocytes, cardiomyocytes, hepatocytes, endothelial, and neuronal cells

Keywords： mesenchymal stem cells     differentiation     immunomodulation     regenerative medicine    

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Implantation of human umbilical cord mesenchymal stem cells for ischemic stroke: perspectives and challenges

Yingchen Li,Guoheng Hu,Qilai Cheng

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 20-29 doi: 10.1007/s11684-014-0371-x

Abstract: As a neuroregenerative therapy, the implantation of human umbilical cord mesenchymal stem cells (hUC-MSCs

Keywords： cellular therapy     transplantation     human umbilical cord     mesenchymal stem cells     ischemic stroke    

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Capacity of human umbilical cord-derived mesenchymal stem cells to differentiate into sweat gland-likecells: a preclinical study

Siming Yang, Kui Ma, Changjiang Feng, Yan Wu, Yao Wang, Sha Huang, Xiaobing Fu

Frontiers of Medicine 2013, Volume 7, Issue 3,   Pages 345-353 doi: 10.1007/s11684-013-0282-2

Abstract:

Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) possess various advantageous propertiespotential, multi-lineage differentiation potential and capacity for differentiating into sweat gland-like cellsculture media (ASFCM) in order to determine their potential for differentiation into sweat gland-like cellsMoreover, cells cultured in ASFCM showed vigorous proliferation comparable to those of cells grown inMorphology of hUC-MSCs cultured in ASFCM was comparable to those of cells grown under classical culture

Keywords： umbilical cord     mesenchymal stem cells     sweat gland     preclinical    

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Transplantation of placenta-derived mesenchymal stem cells in type 2 diabetes: a pilot study

Ranhua JIANG, Zhibo HAN, Guangsheng ZHUO, Xiaodan QU, Xue LI, Xin WANG, Yuankang SHAO, Shimin YANG, Zhong Chao HAN

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 94-100 doi: 10.1007/s11684-011-0116-z

Abstract:

Mesenchymal stem cells (MSC) have been used in clinical trials for severe diabetes, a chronic disease

Keywords： placenta stem cells     treatment of type 2 diabetes    

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Regulatory factors of mesenchymal stem cell migration into injured tissues and their signal transduction

Li LI, Jianxin JIANG

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 33-39 doi: 10.1007/s11684-011-0114-1

Abstract:

Adult stem cells hold great promise for wound healing and tissue regeneration.Mesenchymal stem cells (MSCs), for example, have been shown to play a role in tissue repair.understanding of the molecular mechanisms involved in the migration of MSCs will help us to develop new stem

Keywords： mesenchymal stem cells     migration     molecular mechanisms     signaling pathway    

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Cell therapy for the treatment of reproductive diseases and infertility: an overview from the mechanism to the clinic alongside diagnostic methods

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 827-858 doi: 10.1007/s11684-022-0948-8

Abstract: Besides routine therapeutic methods, stem cells are rapidly being examined as viable alternative therapiesRemarkable progress has been made in understanding the biology and purpose of stem cells.The affected pluripotent stem cells (iPSCs) and mesenchymal stem cells (MSCs) are further studied forthis study discusses current developments in the use of some kinds of MSCs such as adipose-derived stemcells, bone marrow stromal cells, umbilical cord MSCs, and menstrual blood MSCs.

Keywords： infertility     stem cell therapy     mesenchymal stem cells     pluripotent stem cells    

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Extracellular vesicle-carried GTF2I from mesenchymal stem cells promotes the expression of tumor-suppressive

Frontiers of Medicine doi: 10.1007/s11684-023-0999-5

Abstract: Therefore, we selected them for this present study, where the effects of bone marrow mesenchymal stemcell-derived EVs (BMSDs-EVs) enriched with GTF2I were evaluated on the epithelial–to–mesenchymal transitionEctopically expressed GTF2I and FAT1 were found to augment malignant phenotypes of TC cells, EMT, andMSC-EVs could shuttle GTF2I into TPC-1 cells, where GTF2I inhibited TC malignant phenotypes, EMT, and

Keywords： thyroid carcinoma     mesenchymal stem cell     extracellular vesicle     GTF2I     FAT1     CDK4    

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Mesenchymal stem cells and immune disorders: from basic science to clinical transition

Shihua Wang, Rongjia Zhu, Hongling Li, Jing Li, Qin Han, Robert Chunhua Zhao

Frontiers of Medicine 2019, Volume 13, Issue 2,   Pages 138-151 doi: 10.1007/s11684-018-0627-y

Abstract: As a promising candidate seed cell type in regenerative medicine, mesenchymal stem cells (MSCs) haveSpecifically, on the basis of our previous work, we proposed three new concepts of MSCs, i.e., “subtotipotent stem

Keywords： mesenchymal stem cell     clinical transition     immune disorders    

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Immunohistochemical characterization of hepatic stem cell-related cells in developing human liver

XU Jun, HU Yong, WANG Jian, ZHANG Taiping, ZHOU Ji, YU Hongyu

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 264-268 doi: 10.1007/s11684-007-0050-2

Abstract: Little is known about the expression characteristics of the various kinds of possible markers in hepatic stemexpression of hepatic/cholangiocellular differentiation markers (AFP, GST-, CK7, CK19) and hematopoietic stemin the hepatic cords/mesenchymal tissue of portal areas.hepatic mesenchymal tissue of portal areas.It is also indicated that the hematopoietic stem cells may give rise to some HSCs in embryonic liver.

Keywords： origin     Little     mesenchymal tissue     cords/mesenchymal tissue     CD34    

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Clinical study using mesenchymal stem cells for the treatment of patients with severe COVID-19

Lingling Tang, Yingan Jiang, Mengfei Zhu, Lijun Chen, Xiaoyang Zhou, Chenliang Zhou, Peng Ye, Xiaobei Chen, Baohong Wang, Zhenyu Xu, Qiang Zhang, Xiaowei Xu, Hainv Gao, Xiaojun Wu, Dong Li, Wanli Jiang, Jingjing Qu, Charlie Xiang, Lanjuan Li

Frontiers of Medicine 2020, Volume 14, Issue 5,   Pages 664-673 doi: 10.1007/s11684-020-0810-9

Abstract: Mesenchymal stem cell (MSC) therapy is the immediate treatment used for patients with severe cases of

Keywords： coronavirus disease 2019 (COVID-19)     mesenchymal stem cell     acute respiratory distress syndrome     stem cell    

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Separation，Purification and Identification of Rat Bone Marrow Mesenchymal Stem Cells

Zhang Rongli,Feng Xue,Zhang Huiliang,Luo Guoan,Li Lianda ,Wang Yiming

Strategic Study of CAE 2007, Volume 9, Issue 7,   Pages 89-94

Abstract:

Bone marrow mesenchymal stem cells (BMMSCs) were separated by densityThe cells were verified as the BMMSC by the expression of the CSA and the genes.This is a simple and reliable method to obtain BMMSC as stem cell used in cell and tissue engineering

Keywords： rat     bone marrow mesenchymal stem cells(BMMSCs)     flow cytometry    

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Epithelial-to-mesenchymal transition in cancer: complexity and opportunities

Yun Zhang, Robert A. Weinberg

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 361-373 doi: 10.1007/s11684-018-0656-6

Abstract:

The cell-biological program termed the epithelial-to-mesenchymal transition (EMT) plays an importantsignals and intracellular gene circuits of a particular cell, this program can drive fully epithelial cellsto enter into a series of phenotypic states arrayed along the epithelial-mesenchymal phenotypic axisCurrently we still lack a coherent overview of the molecular and biochemical mechanisms inducing cellsto enter various states along the epithelial-mesenchymal phenotypic spectrum.

Keywords： epithelial-to-mesenchymal transition     cancer     metastasis     cancer stem cell    

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Determination of telomerase activity in stem cells and non-stem cells of breast cancer

LI Zhi, HE Yanli, ZHANG Jiahua, ZHANG Jinghui, HUANG Tao

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 294-298 doi: 10.1007/s11684-007-0056-9

Abstract: Although all normal tissue cells, including stem cells, are genetically homologous, variation in geneIn normal adults, telomerase activation mainly presents in tissue stem cells and progenitor cells givingand only minorities of cells, designated as cancer stem cells, undergo processes analogous to the self-renewalIn this study, telomerase activity was measured and compared in breast cancer stem cells and non-stemThe results indicated that cancer stem cells show a higher level of enzyme activity than non-stem cells
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Mesenchymal Stem Cells Represent a Therapeutic Option for Coronavirus Disease 2019-Related Acute Respiratory

Xuan Zhao, Yi Zhang

Engineering 2020, Volume 6, Issue 10,   Pages 1073-1075 doi: 10.1016/j.eng.2020.05.015

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Title Author Date Type Operation

Umbilical cord-derived mesenchymal stem cells: strategies, challenges, and potential for cutaneous regeneration

Siming Yang, Sha Huang, Changjiang Feng, Xiaobing Fu

Journal Article

Mesenchymal stem cells hold promise for regenerative medicine

Shihua Wang, Xuebin Qu, Robert Chunhua Zhao

Journal Article

Implantation of human umbilical cord mesenchymal stem cells for ischemic stroke: perspectives and challenges

Yingchen Li,Guoheng Hu,Qilai Cheng

Journal Article

Capacity of human umbilical cord-derived mesenchymal stem cells to differentiate into sweat gland-likecells: a preclinical study

Siming Yang, Kui Ma, Changjiang Feng, Yan Wu, Yao Wang, Sha Huang, Xiaobing Fu

Journal Article

Transplantation of placenta-derived mesenchymal stem cells in type 2 diabetes: a pilot study

Ranhua JIANG, Zhibo HAN, Guangsheng ZHUO, Xiaodan QU, Xue LI, Xin WANG, Yuankang SHAO, Shimin YANG, Zhong Chao HAN

Journal Article

Regulatory factors of mesenchymal stem cell migration into injured tissues and their signal transduction

Li LI, Jianxin JIANG

Journal Article

Cell therapy for the treatment of reproductive diseases and infertility: an overview from the mechanism to the clinic alongside diagnostic methods

Journal Article

Extracellular vesicle-carried GTF2I from mesenchymal stem cells promotes the expression of tumor-suppressive

Journal Article

Mesenchymal stem cells and immune disorders: from basic science to clinical transition

Shihua Wang, Rongjia Zhu, Hongling Li, Jing Li, Qin Han, Robert Chunhua Zhao

Journal Article

Immunohistochemical characterization of hepatic stem cell-related cells in developing human liver

XU Jun, HU Yong, WANG Jian, ZHANG Taiping, ZHOU Ji, YU Hongyu

Journal Article

Clinical study using mesenchymal stem cells for the treatment of patients with severe COVID-19

Lingling Tang, Yingan Jiang, Mengfei Zhu, Lijun Chen, Xiaoyang Zhou, Chenliang Zhou, Peng Ye, Xiaobei Chen, Baohong Wang, Zhenyu Xu, Qiang Zhang, Xiaowei Xu, Hainv Gao, Xiaojun Wu, Dong Li, Wanli Jiang, Jingjing Qu, Charlie Xiang, Lanjuan Li

Journal Article

Separation，Purification and Identification of Rat Bone Marrow Mesenchymal Stem Cells

Zhang Rongli,Feng Xue,Zhang Huiliang,Luo Guoan,Li Lianda ,Wang Yiming

Journal Article

Epithelial-to-mesenchymal transition in cancer: complexity and opportunities

Yun Zhang, Robert A. Weinberg

Journal Article

Determination of telomerase activity in stem cells and non-stem cells of breast cancer

LI Zhi, HE Yanli, ZHANG Jiahua, ZHANG Jinghui, HUANG Tao

Journal Article

Mesenchymal Stem Cells Represent a Therapeutic Option for Coronavirus Disease 2019-Related Acute Respiratory

Xuan Zhao, Yi Zhang

Journal Article